Syn-Ake research monograph — the Waglerin-mimetic topical anti-wrinkle peptide (cosmetic, not systemic)

Syn-Ake is a cosmetic topical peptide — Dipeptide Diaminobutyroyl Benzylamide Diacetate (CAS 823202-99-9), a synthetic mimic of Waglerin-1 from the venom of the Temple Pit Viper (Tropidolaemus wagleri). It is a topical "Botox-like" anti-wrinkle ingredient (from DSM/Pentapharm) and not an injectable or systemic research peptide.

Class

Cosmetic topical peptide; Dipeptide Diaminobutyroyl Benzylamide Diacetate, a Waglerin-1 mimetic. Single compound.

Mechanism

Syn-Ake mimics Waglerin-1's antagonism of the muscle-type nicotinic acetylcholine receptor (nAChR) at the neuromuscular junction. By blocking acetylcholine-driven contraction it relaxes mimic muscles topically, softening expression lines. In vitro it reportedly blocks muscle contraction by up to about 80%, and it also shows dose-dependent antioxidant (DPPH-scavenging) activity.

Research summary

Important context: the evidence is cosmetic and topical, drawn largely from the ingredient manufacturer and from in-vitro assays, not from independent clinical trials or any systemic research. The reported cosmetic outcome is visible smoothing of expression lines after about 28 days of topical use. There is no injection or systemic evidence base, and Syn-Ake should not be presented as comparable to studied injectable peptides.

Studied protocols

Topical leave-on cosmetic formulations (typically around a 4% Syn-Ake blend), applied daily. There is no studied injectable or systemic protocol.

Stacking research

Cosmetic formulations pair it with other "muscle-relaxing" peptides (for example Argireline / acetyl hexapeptide-8) and with hydrators; combination data are formulation-level cosmetic claims, not research.

Clinical / safety context

A cosmetic topical with a manufacturer tolerability record; it is not a drug, and no systemic exposure is intended or characterized. Despite the "snake-venom" framing it is a synthetic, dilute cosmetic actor — not venom.

Evidence quality — Limited

Cosmetic, manufacturer, and in-vitro data only; no systemic or independent clinical evidence.

Notes

Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake). This is a skincare ingredient; frame it as topical-cosmetic, distinct from the injectable peptide catalogue.