Selank + DSIP ("Dream State") is a vendor blend of two neuropeptides — Selank (an anxiolytic tuftsin analogue) and DSIP (Delta Sleep-Inducing Peptide) — marketed together for calm and sleep.
Class
Blend of two neuropeptides: Selank (anxiolytic) + DSIP (sleep-related). Blend compound.
Mechanism
The two components act through mechanistically distinct pathways. Selank is a synthetic heptapeptide analogue of the immunopeptide tuftsin; it stabilizes enkephalins and produces GABAergic and serotonergic modulation with reduced hypothalamic-pituitary-adrenal (HPA) axis activation, reported to give anxiolysis without sedation, and associated with raised BDNF in anxiety research from the Institute of Molecular Genetics in Moscow. DSIP is a naturally occurring nonapeptide (first isolated in 1977) with pleiotropic effects including delta-wave sleep induction, circadian and neuroendocrine (HPA) normalization, and antioxidant activity. The blend's rationale is dual-pathway: anxiolysis from Selank plus sleep induction from DSIP, addressing the stress-and-insomnia loop together.
Research summary
The combination is mechanistically complementary, but there are no controlled studies of the blend itself — "synergy" claims are vendor or secondary-source, not trial data. Each component individually is studied mostly in Russian and animal research; DSIP's human sleep literature in particular is old and mixed. Indexed grounding for the blend is thin (three general peptide-review documents).
Human clinical trial data
No human clinical trial has established administration parameters for the Selank + DSIP blend; VialTalk does not provide community-sourced dosing.
Clinical / safety context
Neither component is FDA/EMA-approved; both are sold research-use-only. There are no combination safety data, and component safety derives largely from Russian and animal research.
Evidence quality — Limited
The mechanisms are complementary, but the combination is unstudied and the component evidence is preclinical and regional.
Notes
"Dream State" = Selank + DSIP. Cross-reference the standalone Selank and DSIP monographs; this entry covers the rationale for combining them, not their individual records.