Combining GLP-1 peptides with GH secretagogues for body recomp
Discussion
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Interesting stack concept that's getting discussed more: running a GLP-1 agonist alongside GH peptides.
The theory:
- GLP-1 handles appetite suppression and fat loss
- GH secretagogues promote muscle preservation and fat metabolism
- Together, you're hitting body recomposition from two angles
Potential combinations:
- Semaglutide + CJC-1295/Ipamorelin
- Tirzepatide + Tesamorelin
- Low-dose GLP-1 + MK-677 (counteracts MK-677's appetite increase?)
The concern:
- Both GLP-1 agonists and GH can affect blood sugar
- Stacking compounds that both impact insulin/glucose needs careful monitoring
- Not much formal data on these combinations
The MK-677 + GLP-1 idea is interesting because MK-677's biggest complaint (increased hunger) is directly countered by GLP-1's appetite suppression. In theory they offset each other's downsides.
Has anyone combined GLP-1 research with GH peptides? What was the rationale and what did you observe?
3/22/20260
2 Replies
I went a slightly different route, pin Reta and CJC/Ipa (nightly fasted 3hrs from last meal) my weight: 290 down to 258 and skeletal muscle is 43.1% up from 38.9, no hunger and no water retention
4/21/20261
@jason.sowder wrote:
<p>I went a slightly different route, pin Reta and CJC/Ipa (nightly fasted 3hrs from last meal) my weight: 290 down to 258 and skeletal muscle is 43.1% up from 38.9, no hunger and no water retention </p>
Should have also said I’m sticking to my hydration, protein and carbs as well
4/21/20261
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